Overdiagnosis is defined as “when people without symptoms are
diagnosed with a disease that ultimately will not cause them to experience
symptoms or early death.” I think it important to distinguish
overdiagnosis (which most people have never heard of) from false positive test
results (which most people have at least some idea about). Let’s take breast
cancer as an example. If you have a false positive mammogram, it shows a shadow
suggestive of cancer, but when you do a biopsy or more definitive test, they
see no cancer cells. But if you have overdiagnosis, the shadow on the mammogram
actually has cancer cells when looked at under the microscope. The problem is
that some cancer cells never grow very fast or spread, and if you have that
form of indolent cancer (these authors call it “pseudocancer”), finding out
about it early produces no benefit for you. You’ll have treatments to attack
the cancer, and those treatments will cause serious side effects, and you’ll be
forever labeled a “cancer patient,” but if the “disease” had simply been left
alone, you’d never have known the difference. (Most lay people, I would wager,
have no idea that there exists a form of “cancer” that can act like this.)
The authors list a number of causes of overdiagnosis: while one
big one is screening tests, others are increasingly sensitive tests that find
smaller and smaller abnormalities, and redefinitions of “disease” that include
more people with milder cases. The authors mention a study of asthma which
found that nearly 30% of people diagnosed as such did not really have asthma
after all, and 66% of those diagnosed did not need any medicines for it. (The
irony here is that we also know that there are people with true asthma who
remain underdiagnosed and untreated, too often fatally so.)
The authors list these conditions as currently subject to
overdiagnosis (again, not to deny that at least some people with these
conditions are currently underdiagnosed and/or lack access to proper care):
·
Asthma
·
Attention deficit-hyperactivity disorder
·
Breast cancer
·
Chronic kidney disease
·
Pregnancy-related diabetes
·
High blood pressure
·
High cholesterol
·
Lung cancer
·
Osteoporosis
·
Prostate cancer
·
Pulmonary embolism (blood clots in lung)
·
Thyroid cancer
So why does all this happen? Improved technology is one big
reason, along with our love affair with screening and “prevention” and our
near-religious faith that early diagnosis is always good. But coming right up
next on the list is commercial influence, with the companies that make money
off the screening tests and the companies that make money off the drugs and
devices that are then prescribed when more people are labeled as sick doing
everything they can to move the curve in the direction of overdiagnosis.
(Indeed, if you look back at Don Light’s and my article on the Inverse Benefit
Law:
http://brodyhooked.blogspot.com/2011/01/inverse-benefit-law-making-sense-of-how.html--and review the forces that produce what we called the “left shift” that categorizes more and more previously healthy people as candidates for drug therapy, you’ll see a lot of overlap with the factors described in this paper.)
Moynihan R, Doust J, Henry D. Preventing overdiagnosis: how to stop
harming the healthy. BMJ 2012;
344:e3502.